Resources

News

April 2016

Bracco Press Release: First Approval by U.S. Food and Drug Administration for Contrast Enhanced Ultrasonography of the Liver Received by Bracco Diagnostics Inc. for LUMASON® (sulfur hexafluoride lipid-type A microspheres) for injectable suspension, for intravenous use. 

HIGHLIGHTS OF LUMASON® PRESCRIBING INFORMATION

June 16, 2014

Editorial: Sellars ME, Deganello A, Sidhu PS. Paediatric Contrast-Enhanced Ultrasound (CEUS): A Technique that Requires Co-operation for Rapid Implementation into Clinical Practice. Ultraschall in Med 2014; 35: 203-206

October 2, 2012

Dr Kassa Darge has been invited to serve on the board of the International Contrast Ultrasound Society (ICUS) as the representative of the SPR. The two organizations are linking web pages, and there will be collaboration between ICUS and the SPR contrast ultrasound task force.
 
August 24, 2012

After a review of GE Healthcare's March 2012 Supplemental New Drug Application for proposed label changes, the U.S. Food and Drug Administration, or FDA, made revisions to the Prescribing Information for Optison, including removal of the statement, "In patients with pulmonary hypertension or unstable cardiopulmonary conditions, monitor vital sign measurements, electrocardiography and cutaneous oxygen saturation during and for at least 30 minutes after Optison administration", from within the previous BOXED WARNING. Similar language was also removed from the WARNING section of the label.
 
July 3, 2012

There will be a pediatric contrast ultrasound sunrise session at the SPR meeting in San Antonio on Friday morning, May 17, 2013. Many of our national leaders in this exciting emerging modality will be speaking.
 
March 28, 2012

New Images/Cases added above - IRR-VUR in meggaureter - Kassa Darge, MD, PhD & Liver Laceration & Kidney Perfursion defect Not Seen On Grey-Scale Ultrasound - Doris Franke, MD
 
March 23, 2012

The Contrast Ultrasound Task Force will be meeting in San Francisco at the SPR Annual Meeting. During the meteting, there will be discussions on relationships with manufacturers, off-label use, and investigator sponsored trials. The Task Force is hoping to have a session on Contrast Ultrasound at the 2013 SPR Annual Meeting in San Antonio, Texas.
 
September 22-23, 2011

International Contrast Ultrasound Society Bubble Conference Update. The ICUS meeting took place September 22-23 in Chicago. It was an interesting mix of bench scientists, cardiologists, and radiologists. The first part was a summary of current efforts to promote contrast ultrasound approval by ultrasound societies around the world.

Technique

 

Applications

  • Intervenous
  • Intravesical

Safety

 

Conference

ICUS links to Meetings 

2015

 King’s College Hospital, London, United Kingdom, June 25-26, 3rd International Paediatric Contrast-enhanced Ultrasound (CEUS) Course (With Live Cases) 

2014

 

International Pediatric Contrast-Enhanced Ultrasound Course 2014:  Faculty members (left to right)
Liam Woods, Annamaria Deganello, Kasse Darge, Maria Sellars, Paul Sidhu, David Cosgrove, Sanjay Bansal, Tim Yusuf
.

 

Publications

Downloadable Spreadsheet - Publications 2014-2016 

Title Author
Off-label use of ultrasound 1 contrast agents for intravenous
applications in children – an analysis of the existing literature
1 Dr. Elsa Rosado, Department of radiology, Hospital
Prof. Doutor Fernado Fonseca, Amadora, Portugal
2 Prof. Dr. Michael Riccabona, Department of Radiology, Division of Paediatric Radiology, Universitätsklinikum LKH Graz, Austria
Guidelines (from ICUS Website)
Contrast‐enhanced Ultrasound Bibliography
Accuracy of contrast‑enhanced ultrasound (CEUS) in the
identification and characterization of traumatic solid organ
lesions in children: a retrospective comparison with baseline
US and CE‑MDCT
Guendalina Menichini1 · Barbara Sessa1 · Margherita Trinci1 · Michele Galluzzo1 ·
Vittorio Miele1
Safety of Perflutren Ultrasound Contrast Agents:
A Disproportionality Analysis of the US FAERS Database
Manfred Hauben1,3
• Eric Y. Hung3
• Kelly C. Hanretta2
• Sripal Bangalore1
• Vincenza Snow3
Paediatric Contrast-Enhanced Ultrasound (CEUS): A Technique that Requires Co-operation for Rapid Implementation into Clinical Practice. Sellars ME, Deganello A, Sidhu PS.
Voiding urosonography with second-generation ultrasound
contrast versus micturating cystourethrography in the diagnosis of vesicoureteric reflux L. S.
L. S. Wong & K. S. Tse & T. W. Fan & K. Y. Kwok &
T. K. Tsang & H. S. Fung & W. Chan & K. W. Lee &
M. W. Y. Leung & N. S. Y. Chao & K.W. Tang & S. C. H Chan
Voiding urosonography with second-generation ultrasound contrast versus micturating cystourethrography in the diagnosis of vesicoureteric reflux. Wong LS, et al:
Cortical Necrosis secondary to Trauma in a Child: Contrast Ultrasound Comparable to Magnetic Resonance Imaging Yusuf,G et al
Paediatric Contrast-Enhanced Ultrasound (CEUS): A Technique that Requires Co-operation for Rapid Implementation into Clinical Practice. Editorial: Sellars ME, Deganello A, Sidhu PS.

 

Archival Publications

Downloadable spreadsheet - Publications from 2013 and before 

Safety of Ultrasound Contrast Agents in Patients With Known
or Suspected Cardiac Shunts
Jeremy M. Parker, MDa, Mark W. Weller, JDb, Linda Maiman Feinstein, JDb, Robin J. Adams, BSb,
Michael L. Main, MDc, Paul A. Grayburn, MDd, David O. Cosgrove, MDe, Barry A. Goldberg, MDf,
Kassa Darge, MD, PhDg, Petros Nihoyannopoulos, MDh, Stephanie Wilson, MDi, Mark Monaghan, PhDj,
Fabio Piscaglia, MDk, Brian Fowlkes, PhDl, Wilson Mathias, MDm, Fuminari Moriyasu, MD, PhDn,
Maria Christina Chammas, MD, PhDm, Lennard Greenbaum, MDo, and Steven B. Feinstein, MDa,*
Contrast enhanced ultrasound (CEUS) in blunt abdominal trauma. Cagini, L et al
Transfontanellar contrast enhanced ultrasound in infants: Initial experience. Kastler A, et al.
Contrast-enhanced transcranial Doppler ultrasonography in the diagnosis of brain death. Welschehold, S. et al
Safety of Contrast Enhanced Ultrasound in Children for Non-cardiac Applications: A Review by the Society for Pediatric Radiology (SPR) and The International Contrast Ultrasound Society (ICUS). Darge K et al
Contrast Enhanced Ultrasound (CEUS) Characterization of Grey-Scale Sonographic Indeterminate Focal Liver Lesions in Pediatric Practice. Jacob J et al

Serial voiding urosonography: a safe technique for the study of the entire urinary tract in children. [Article in Spanish]
Duran C1, del Riego J, Riera L. 1Departamento de Radiología, UDIAT-CD, Corporació Sanitària i Universitària Parc Taulí -UAB, Sabadell, Barcelona, España. cduran@tauli.cat
Safety of contrast-enhanced ultrasound
in children for non-cardiac applications: a review
by the Society for Pediatric Radiology (SPR)
and the International Contrast Ultrasound Society (ICUS)
Kassa Darge & Frederica Papadopoulou & Aikaterini Ntoulia & Dorothy I. Bulas & Brian D. Coley & Lynn A. Fordham & Harriet J. Paltiel & Beth McCarville & Frank M. Volberg & David O. Cosgrove & Barry B. Goldberg & Stephanie R. Wilson & Steven B. Feinstein
Application of a second-generation US contrast agent
in infants and children—a European questionnaire-based survey
Michael Riccabona
Contrast-enhanced sonography of malignant pediatric
abdominal and pelvic solid tumors: preliminary safety
and feasibility data
M. Beth McCarville & Sue C. Kaste & Fredric A. Hoffer &
Raja B. Khan & R. Christopher Walton &
Bruce S. Alpert &Wayne L. Furman & Chenghong Li &
Xiaoping Xiong
The EFSUMB Guidelines and Recommendations on the
Clinical Practice of Contrast Enhanced Ultrasound
(CEUS): Update 2011 on non-hepatic applications
F. Piscaglia1, C. Nolsøe2, C. F. Dietrich3, D. O. Cosgrove4, O. H. Gilja5, M. Bachmann Nielsen6, T. Albrecht7, L. Barozzi8,
M. Bertolotto9, O. Catalano10, M. Claudon11, D. A. Clevert12, J. M. Correas13, M. D’Onofrio14, F. M. Drudi15, J. Eyding16,
M. Giovannini17, M. Hocke18, A. Ignee19, E. M. Jung20, A. S. Klauser21, N. Lassau22, E. Leen23, G. Mathis24, A. Saftoiu25,
G. Seidel26, P. S. Sidhu27, G. ter. Haar28, D. Timmerman29, H. P.Weskott30
ESPR Uroradiology Task Force and
ESUR Paediatric Working Group—
Imaging recommendations in paediatric
uroradiology, Part V: childhood
cystic kidney disease, childhood renal
transplantation and contrast-enhanced
ultrasonography in children
Michael Riccabona & Fred Efraim Avni &
Maria Beatrice Damasio & Lil-Sofie Ording Müller &
Johan G. Blickman & Kassa Darge & Maria Luisa Lobo &
Frederica Papadopoulou & Pierre-Hugues Vivier &
Ullrich Willi
Intravenous Application of Second-Generation Ultrasound Contrast Agents in Children: A Review of the Literature. Piskunowicz M et al
The Contrast Ultrasound Task Force will be meeting in San Francisco at the SPR Annual Meeting. During the meteting, there will be discussions on relationships with manufacturers, off-label use, and investigator sponsored trials. The Task Force is hoping to have a session on Contrast Ultrasound at the 2013 SPR Annual Meeting in San Antonio, Texas.
New Images/Cases added above - IRR-VUR in meggaureter - Kassa Darge, MD, PhD & Liver Laceration & Kidney Perfursion defect Not Seen On Grey-Scale Ultrasound - Doris Franke, MD
There will be a pediatric contrast ultrasound sunrise session at the SPR meeting in San Antonio on Friday morning, May 17, 2013. Many of our national leaders in this exciting emerging modality will be speaking.
After a review of GE Healthcare's March 2012 Supplemental New Drug Application for proposed label changes, the U.S. Food and Drug Administration, or FDA, made revisions to the Prescribing Information for Optison, including removal of the statement, "In patients with pulmonary hypertension or unstable cardiopulmonary conditions, monitor vital sign measurements, electrocardiography and cutaneous oxygen saturation during and for at least 30 minutes after Optison administration", from within the previous BOXED WARNING. Similar language was also removed from the WARNING section of the label.
Dr Kassa Darge has been invited to serve on the board of the International Contrast Ultrasound Society (ICUS) as the representative of the SPR. The two organizations are linking web pages, and there will be collaboration between ICUS and the SPR contrast ultrasound task force.

Voiding urosonography including urethrosonography: high-quality examinations with an optimised procedure using a second-generation US contrast agent.
Duran C1, del Riego J, Riera L, Martin C, Serrano C, Palaña P. Department of Radiology, UDIAT-Centre Diagnòstic, Institut Universitari Parc Taulí-UAB, Parc Taulí, Sabadell, 08208 Barcelona, Spain. cduran@tauli.cat
ESPR Uroradiology Task Force and ESUR Paediatric Working Group—Imaging recommendations in paediatric uroradiology, Part V: childhood cystic kidney disease, childhood renal transplantation and contrast-enhanced ultrasonography in children Michael Riccabona, Fred Efraim Avni, Maria Beatrice Damasio, Lil-Sofie Ording Müller, Johan G. Blickman, Kassa Darge, Maria Luisa Lobo, Frederica Papadopoulou, Pierre-Hugues Vivier, Ullrich Willi
ESPR Uroradiology Task Force and ESUR Paediatric Working
Group—Imaging recommendations in paediatric uroradiology,
Part V: childhood cystic kidney disease, childhood renal
transplantation and contrast-enhanced ultrasonography
in children
Michael Riccabona & Fred Efraim Avni &
Maria Beatrice Damasio & Lil-Sofie Ording-Müller &
Johan G. Blickman & Kassa Darge & Maria Luisa Lobo &
Frederica Papadopoulou & Pierre-Hugues Vivier &
Ullrich Willi
International Contrast Ultrasound Society Bubble Conference Update. The ICUS meeting took place September 22-23 in Chicago. It was an interesting mix of bench scientists, cardiologists, and radiologists. The first part was a summary of current efforts to promote contrast ultrasound approval by ultrasound societies around the world.

Voiding urosonography with a second-generation contrast agent versus voiding cystourethrography.
Del Riego J, Duran C, Riera Soler L.
Contrast-enhanced sonography in pediatrics M. Beth McCarville
Contrast-enhanced US (CEUS) in children: ready for prime
time in the United States
Kassa Darge & On behalf the CEUS task force
of the Society for Pediatric Radiology
Contrast-enhanced sonography in pediatrics M. Beth McCarville
Molecular ultrasound imaging and its potential for paediatric radiology Isabel Kiessling & Jessica Bzyl & Fabian Kiessling
Ultrasound detection of vesicoureteral reflux in children. Novljan G1, Levart TK, Kljucevsek D, Kenig A, Kenda RB. 1Department of Pediatric Nephrology and Pediatric Radiology Unit (DK,
Voiding urosonography with second-generation contrast agent versus voiding cystourethrography. Kis E1, Nyitrai A, Várkonyi I, Máttyus I, Cseprekál O, Reusz G, Szabó A. 11st Department of Pediatrics, Pediatric Radiology Unit, Semmelweis Medical University, 53-54 Str. János Bókay, Budapest, Hungary. kiseva2009@gmail.com
Voiding urosonography with US contrast agent for the diagnosis of vesicoureteric reflux in children: an update Kassa Darge
Voiding urosonography with US contrast agent for the diagnosis of vesicoureteric reflux in children: an update Kassa Darge
Voiding urosonography: the study of the urethra is no longer a limitation of the technique. Duran C1, Valera A, Alguersuari A, Ballesteros E, Riera L, Martin C, Puig J. 1Department of Diagnostic Radiology, UDIAT-SDI, Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona, 08208, Spain. cduran@tauli.cat
Contrast-enhanced voiding urosonography and genitography in a baby with ambiguous genitalia and urogenital sinus Kopac M1, Riccabona M, Haim M 1matjaz.kopac@siol.net
Guidelines and Good Clinical Practice Recommendations
for Contrast Enhanced Ultrasound (CEUS) –
Update 2008
M. Claudon1, D. Cosgrove2, T. Albrecht3, L. Bolondi4, M. Bosio5, F. Calliada6, J.-M. Correas7, K. Darge8, C. Dietrich9,
M. D'Onofrio10, D. H. Evans11, C. Filice12, L. Greiner13, K. Jäger14, N. de. Jong15, E. Leen16, R. Lencioni17, D. Lindsell18,
A. Martegani19, S. Meairs20, C. Nolsøe21, F. Piscaglia22, P. Ricci23, G. Seidel24, B. Skjoldbye25, L. Solbiati26, L. Thorelius27,
F. Tranquart28, H. P.Weskott29, T.Whittingham30
Voiding urosonography with ultrasound contrast agents for the diagnosis of vesicoureteric reflux in children. I. Procedure Kassa Darge
Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations Kassa Darge
Voiding urosonography with ultrasound contrast agents
for the diagnosis of vesicoureteric reflux in children
I. Procedure
Kassa Darge
Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children II. Comparison with radiological examinations Kassa Darge
Voiding ultrasonography: evaluation of the detection of vesicoureteral reflux based on the review of digital ultrasound clips Galloy MA1, Guillemin F, Couture A, Pracros JP, Didier F, Ducou Le Pointe H, Pefoubou Y, Aubert D, Lortat-Jacob S, Roederer T, Claudon M.: 1Radiology, INSERM, ERI 13, Children's University Hospital Nancy.
Voiding urosonography as first step in the diagnosis of vesicoureteral reflux in children: a clinical experience. Giordano M1, Marzolla R, Puteo F, Scianaro L, Caringella DA, Depalo T. 1Pediatric Nephrology and Dialysis Unit, Pediatric Hospital Giovanni XXIII, Via Amendola 207, 70126 Bari, Italy. mariogiordanobari@fastwebnet.it
Contrast-enhanced ultrasonography (voiding urosonography) of vesicoureteral reflux: state of the art. Article in English, Italian Zimbaro G1, Ascenti G, Visalli C, Bottari A, Zimbaro F, Martino N, Mazziotti S. 1Dipartimento di Scienze Radiologiche, Università degli Studi di Messina, Azienda Ospedaliera Universitaria Policlinico G. Martino, Via Consolare Valeria 2, Messina, Italy.
Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low? Papadopoulou F1, Tsampoulas C, Siomou E, Tzovara J, Siamopoulou A, Efremidis SC. 1Department of Clinical Radiology and Imaging, Ioannina University Hospital, Ioannina, 45110, Greece. frpapad@cc.uoi.gr
Contrast-enhanced triggered harmonic sonography for assessment of periarticular hemodynamic changes in experimental arthritis Andrea S. Doria, Raffi Karshafian, Rahim Moineddin, Arun Mohanta, Anguo Zhong, Maria Mendes, Kenneth Pritzker, Roland Jong, Peter Burns
Contrast-enhanced ultrasound in non-operative management of pancreatic injury in childhood Massimo Valentino, Stefania Sartoni Galloni, Maria Rita Rimondi, Andrea Gentili, Mario Lima, Libero Barozzi
Imaging of paediatric splenic injury with contrast-enhanced ultrasonography Anja Oldenburg, Joachim Hohmann, Jan Skrok, Thomas Albrecht
Cyclic voiding urosonography in detecting vesicoureteral reflux in children. Novljan G1, Kenig A, Rus R, Kenda RB. 1Department of Pediatric Nephrology, University Medical Center Ljubljana, Children's Hospital, Stare pravde 4, 1000 Ljubljana, Slovenia. gregor.novljan@mf.uni-lj.si
Simultaneous voiding cystourethrography and voiding urosonography reveals utility of sonographic diagnosis of vesicoureteral reflux in children. Nakamura M1, Shinozaki T, Taniguchi N, Koibuchi H, Momoi M, Itoh K. 1Department of Clinical Laboratory Medicine, Jichi Medical School, Tochigi, Japan. chiko@jichi.ac.jp
Contrast ultrasound of the urethra in children. Maté A1, Bargiela A, Mosteiro S, Diaz A, Bello MJ. Author information 1Department of Radiology, Hospital Juan Canalejo, Xubias de Arriba 84, 15006 A Coruña, Spain. amelia_bargiela@canalejo.org
Vesicoureteral reflux: comparison between urosonography and radionuclide cystography. Ascenti G1, Zimbaro G, Mazziotti S, Chimenz R, Baldari S, Fede C.
Voiding urosonography with ultrasonography contrast medium in children. Mentzel HJ1, Vogt S, John U, Kaiser WA. 1Institute for Diagnostic and Interventional Radiology, University of Jena, Bachstrasse 18, 07740 Jena, Germany. hans-joachim.mentzel@med.uni-jena.de
Cyclic voiding urosonography for detecting vesicoureteric reflux in renal transplant recipients. Kenda RB1, Kenig A, Novljan G, Ponikvar R, Ponikvar JB. 1Department of Pediatric Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia. rajko.kenda@mf.uni-lj.si
Potential pediatric applications for US contrast agents: lessons from the laboratory George A.Taylor

Vendor Information

Introduction

 

Definity

Hitachi Aloka

Lumason

Mindray

  1. Company: Shenzhen Mindray Bio-Medical Electronics Co.,LTD
    Mindray Building, Keji 12th Road South, High-tech Industrial Park, Nanshan, Shenzhen 518057, P.R. China
    Tel: +86755 86119580
    www.mindray.com/ultrasound
  2. Name of US contrast package: UWN Contrast Imaging™ (Ultra-Wideband Nonlinear Contrast Imaging)
  3. Parameters:
    a. Low-MI : available, MI visible on images
    b. High MI : available
    c. Dual screen: available
    d. Color overlay : available
    e. "Subtraction option" : not available
  4. Components of the US contrast modality:
    UWN Contrast Imaging™ provides exceptional contrast agent detecting capability, not only extracts second harmonica, but also non-linear fundamental signals.
  5. US scanners: (Does this mean transducer available for Contrast imaging?)
    a. DC-8:C5-2E,C7-3E, L12-3E,P4-2NE
    b. M9:C5-1s,SP5-1s
  6. Availability: only available on DC-8, M9.
  7. Sample images: as linked below
    1. Liver cancer contrast image
    2. Cholecystic Polypus contrast image
  8. Format: as linked here.  

Optison

Philips

Siemens

Toshiba

Task Force Objectives

  • Help promote contrast ultrasound (CEUS) as a useful, low cost, radiation free imaging modality in pediatric imaging.
  • Develop relationships with manufacturers, regulators, media, other imaging organizations, and appropriate advocacy groups.
  • Explore ways of developing CEUS as a useful, practical imaging tool, including clinical trials and off label use.
  • Encourage scientific research involving CEUS
  • Help educate SPR members, pediatricans, and parents about the benefits of CEUS in pediatric imaging.
  • Help coordinate/support multicenter clinical trials involving CEUS

US-Contrast Enhanced Committee

Roster

Kassa Darge,MD, Chair
M. Beth McCarville, MD
Susan J. Back, MD
Carol E. Barnewolt, MD
Dorothy Bulas, MD
Jamie L. Coleman, MD
Jonathan R. Dillman, MD
Lynn Fordham, MD
Martha Munden, MD
Harriet Paltiel, MD
Frank M. Volberg, Jr, MD



 

Links to Organizations

Images/Cases

Dr Paul Sidhu, Dr Maria Sellars, and Dr Annamaria Deganello at Kings College Hospital, London

Child with Focal Nodular Hyperplasia, with early enhancement, demonstration of central scar, and prolonged enhancement, effectively excluding malignancy.

@Carmina Duran. MD. UDIAT-SDI, Corporació Sanitària i Universitària Parc Taulí, Sabadell, Spain.

Urethra Normal

Posterior urethral valve

ceVUS video clip shoing vesicoureteral reflux, with a normal urethra on transperineal voiding images

  

                                                                                                 

 

 

 

@Frederica Papadopoulou, MD; Thessoloniki, Greece

@Beth McCarville, MD

Contrast Enhanced CT shows Liver Metastasis from Transitional Cell Carcinoma in a 16 year old boy.

Non-Contrast Enhanced Sagittal Ultrasound Image using Contrast Specific Software. Background tissue appears blue.

 

Early Arterial Phae after IV administration of a perflutren contrast agent. The contrast agent appears orange. The liver metastasis shows enhancement during this phase.

Portal-venous phase shows washout of contrast from the metastasis, a feature typical of malignant liver lesions.

  

 

@Kassa Darge, MD, PhD

 

           

CEUS with the bladder full of microbubbles and refluxing into the right ureter. Clear depiction of a right vesicoureteric reflux. No reflux on the left. Contrast specific technique with color overlay and subtraction makes the reflux detection much easier

 

CEUS with microbubbles in the right renal pelvis which is not markedly dilated. Contrast specific technique with color overlay and subtraction makes the reflux detection much easier

@Kassa Darge, MD, PhD

 

 

 

Contrast-enhanced image with color overlay showing reflux into the intrarenal collecting system.

 

Contrast-enhanced image with color overlay showing reflux, with grey scale subtracted.

@Kassa Darge, MD, PhD

CeVUS - Liver Laceration & Kidney Perfusion Defect Not Seen On Grey-Scale Ultrasound

@Doris Franke, MD - Medizinische Hochschule Hannover

 No definite abnormality seen

Small hematoma in hepato-renal space

 

 

Y-Shaped liver laceration and major perfusion defect lower pole, right kidney