Contrast-Enhanced Ultrasound Task Force

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Publications - October 2015

1.     Radiologia. 2013 Mar-Apr;55(2):160-6. doi: 10.1016/j.rx.2012.03.002. Epub 2012 Jun 6.
Serial voiding urosonography: a safe technique for the study of the entire urinary tract in children.  [Article in Spanish] Duran C1, del Riego J, Riera L1Departamento de Radiología, UDIAT-CD, Corporació Sanitària i Universitària Parc Taulí -UAB, Sabadell, Barcelona, España. cduran@tauli.cat

2.     Pediatr Radiol. 2012 Jun;42(6):660-7. doi: 10.1007/s00247-012-2360-z. Epub 2012 May 12.
Voiding urosonography including urethrosonography: high-quality examinations with an optimised procedure using a second-generation US contrast agent.  Duran C1, del Riego J, Riera L, Martin C, Serrano C, Palaña P. Department of Radiology, UDIAT-Centre Diagnòstic, Institut Universitari Parc Taulí-UAB, Parc Taulí, Sabadell, 08208 Barcelona, Spain.
cduran@tauli.cat

3.     Pediatr Nephrol. 2011 Oct;26(10):1913-4. doi: 10.1007/s00467-011-1849-2. Epub 2011 Jul 8.
Voiding urosonography with a second-generation contrast agent versus voiding cystourethrography. Del Riego J, Duran C, Riera Soler L.

4.     Pediatr Nephrol. 2010 Nov;25(11):2289-93. doi: 10.1007/s00467-010-1618-7. Epub 2010 Aug 5.
Voiding urosonography with second-generation contrast agent versus voiding cystourethrography. Kis E1, Nyitrai A, Várkonyi I, Máttyus I, Cseprekál O, Reusz G, Szabó A. 11st Department of Pediatrics, Pediatric Radiology Unit, Semmelweis Medical University, 53-54 Str. János Bókay, Budapest, Hungary. kiseva2009@gmail.com

5.     J Urol. 2010 Jul;184(1):319-24. doi: 10.1016/j.juro.2010.01.057. Epub 2010 May 20.
Ultrasound detection of vesicoureteral reflux in children. Novljan G1, Levart TK, Kljucevsek D, Kenig A, Kenda RB. 1Department of Pediatric Nephrology and Pediatric Radiology Unit (DK,

6.     Ultraschall Med. 2009 Jun;30(3):299-300. doi: 10.1055/s-0028-1109353. Epub 2009 Jun 2.
Contrast-enhanced voiding urosonography and genitography in a baby with ambiguous genitalia and urogenital sinus. Kopac M1, Riccabona M, Haim M 1matjaz.kopac@siol.net

7.     Pediatr Radiol. 2009 Feb;39(2):124-31. doi: 10.1007/s00247-008-1050-3. Epub 2008 Nov 11.
Voiding urosonography: the study of the urethra is no longer a limitation of the technique. Duran C1, Valera A, Alguersuari A, Ballesteros E, Riera L, Martin C, Puig J. 1Department of Diagnostic Radiology, UDIAT-SDI, Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona, 08208, Spain.
cduran@tauli.cat

8.     Ultraschall Med. 2008 Feb;29(1):53-9. Epub 2007 Dec 21.
Voiding ultrasonography: evaluation of the detection of vesicoureteral reflux based on the review of digital ultrasound clips. Galloy MA1, Guillemin F, Couture A, Pracros JP, Didier F, Ducou Le Pointe H, Pefoubou Y, Aubert D, Lortat-Jacob S, Roederer T, Claudon M.: 1Radiology, INSERM, ERI 13, Children's University Hospital Nancy.

9.     Radiol Med. 2007 Dec;112(8):1211-24. Epub 2007 Dec 13.
Contrast-enhanced ultrasonography (voiding urosonography) of vesicoureteral reflux: state of the art. [Article in English, Italian] Zimbaro G1, Ascenti G, Visalli C, Bottari A, Zimbaro F, Martino N, Mazziotti S. 1Dipartimento di Scienze Radiologiche, Università degli Studi di Messina, Azienda Ospedaliera Universitaria Policlinico G. Martino, Via Consolare Valeria 2, Messina, Italy.

10.   Pediatr Radiol. 2007 Jul;37(7):674-7. Epub 2007 May 23.
Voiding urosonography as first step in the diagnosis of vesicoureteral reflux in children: a clinical experience.  Giordano M1, Marzolla R, Puteo F, Scianaro L, Caringella DA, Depalo T. 1Pediatric Nephrology and Dialysis Unit, Pediatric Hospital Giovanni XXIII, Via Amendola 207, 70126 Bari, Italy.
mariogiordanobari@fastwebnet.it

11.   Eur Radiol. 2006 Nov;16(11):2521-6. Epub 2006 Apr 26.
Cyclic contrast-enhanced harmonic voiding urosonography for the evaluation of reflux. Can we keep the cost of the examination low?  Papadopoulou F1, Tsampoulas C, Siomou E, Tzovara J, Siamopoulou A, Efremidis SC.    1Department of Clinical Radiology and Imaging, Ioannina University Hospital, Ioannina, 45110, Greece.
frpapad@cc.uoi.gr

12.   Acta Paediatr. 2003 Dec;92(12):1422-6.
Simultaneous voiding cystourethrography and voiding urosonography reveals utility of sonographic diagnosis of vesicoureteral reflux in children.  Nakamura M1, Shinozaki T, Taniguchi N, Koibuchi H, Momoi M, Itoh K.    1Department of Clinical Laboratory Medicine, Jichi Medical School, Tochigi, Japan.
chiko@jichi.ac.jp

13.   Pediatr Nephrol. 2003 Oct;18(10):992-5. Epub 2003 Jul 29.
Cyclic voiding urosonography in detecting vesicoureteral reflux in children.  Novljan G1, Kenig A, Rus R, Kenda RB.    1Department of Pediatric Nephrology, University Medical Center Ljubljana, Children's Hospital, Stare pravde 4, 1000 Ljubljana, Slovenia. gregor.novljan@mf.uni-lj.si

14.   Eur Radiol. 2003 Jul;13(7):1534-7. Epub 2003 Jan 22.
Contrast ultrasound of the urethra in children.  Maté A1, Bargiela A, Mosteiro S, Diaz A, Bello MJ
Author information  1Department of Radiology, Hospital Juan Canalejo, Xubias de Arriba 84, 15006 A Coruña, Spain. amelia_bargiela@canalejo.org

15.   Pediatr Nephrol. 2003 Aug;18(8):768-71. Epub 2003 Jun 11.
Vesicoureteral reflux: comparison between urosonography and radionuclide cystography.  Ascenti G1, Zimbaro G, Mazziotti S, Chimenz R, Baldari S, Fede C.

16.   Pediatr Nephrol. 2002 Apr;17(4):272-6. 
Voiding urosonography with ultrasonography contrast medium in children. Mentzel HJ1, Vogt S, John U, Kaiser WA1Institute for Diagnostic and Interventional Radiology, University of Jena, Bachstrasse 18, 07740 Jena, Germany. hans-joachim.mentzel@med.uni-jena.de

17.   Nephrol Dial Transplant. 2001 Nov;16(11):2229-31.
Cyclic voiding urosonography for detecting vesicoureteric reflux in renal transplant recipients. Kenda RB1, Kenig A, Novljan G, Ponikvar R, Ponikvar JB. 1Department of Pediatric Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia. rajko.kenda@mf.uni-lj.si

 

 

Recent Publications on Pediatric Contrast Ultrasound

ceVUS Articles by Dr. Kassa Darge

Articles from Pediatric Radiology

  • ESPR Uroradiology Task Force and ESUR Paediatric Working Group—Imaging recommendations in paediatric uroradiology, Part V: childhood cystic kidney disease, childhood renal transplantation and contrast-enhanced ultrasonography in children
    Authors: Michael Riccabona, Fred Efraim Avni, Maria Beatrice Damasio, Lil-Sofie Ording Müller, Johan G. Blickman, Kassa Darge, Maria Luisa Lobo, Frederica Papadopoulou, Pierre-Hugues Vivier, Ullrich Willi
  • Contrast-enhanced ultrasound in non-operative management of pancreatic injury in childhood
    Authors: Massimo Valentino, Stefania Sartoni Galloni, Maria Rita Rimondi, Andrea Gentili, Mario Lima, Libero Barozzi
  • Imaging of paediatric splenic injury with contrast-enhanced ultrasonography
    Authors: Anja Oldenburg, Joachim Hohmann, Jan Skrok, Thomas Albrecht
  • Contrast-enhanced sonography in pediatrics
    Author: M. Beth McCarville
  • Contrast-enhanced triggered harmonic sonography for assessment of periarticular hemodynamic changes in experimental arthritis 
    Authors: Andrea S. Doria, Raffi Karshafian, Rahim Moineddin, Arun Mohanta, Anguo Zhong, Maria Mendes, Kenneth Pritzker, Roland Jong, Peter Burns
  • Potential pediatric applications for US contrast agents: lessons from the laboratory
    Author: George A.Taylor
  • Molecular ultrasound imaging and its potential for paediatric radiology
    Authors: Isabel Kiessling & Jessica Bzyl & Fabian Kiessling

Contrast-Enhanced Ultrasound Bibliography

 

ESPR Uroradiology Task Force and ESUR Paediatric Working Group

 

Guidelines (from ICUS site)

 

Conferences

Conference List

International Pediatric Contrast-Enhanced Ultrasound Course

2015

 King’s College Hospital, London, United Kingdom, June 25-26, 3rd International Paediatric Contrast-enhanced Ultrasound (CEUS) Course (With Live Cases) 

2014

International Pediatric Contrast-Enhanced Ultrasound Course 2014:  Faculty members (left to right)
Liam Woods, Annamaria Deganello, Kasse Darge, Maria Sellars, Paul Sidhu, David Cosgrove, Sanjay Bansal, Tim Yusuf
.

 

Vendor Information

Introduction

 

Hitachi Aloka

Mindray

  1. Company: Shenzhen Mindray Bio-Medical Electronics Co.,LTD
    Mindray Building, Keji 12th Road South, High-tech Industrial Park, Nanshan, Shenzhen 518057, P.R. China
    Tel: +86755 86119580
    www.mindray.com/ultrasound
  2. Name of US contrast package: UWN Contrast Imaging™ (Ultra-Wideband Nonlinear Contrast Imaging)
  3. Parameters:
    a. Low-MI : available, MI visible on images
    b. High MI : available
    c. Dual screen: available
    d. Color overlay : available
    e. "Subtraction option" : not available
  4. Components of the US contrast modality:
    UWN Contrast Imaging™ provides exceptional contrast agent detecting capability, not only extracts second harmonica, but also non-linear fundamental signals.
  5. US scanners: (Does this mean transducer available for Contrast imaging?)
    a. DC-8:C5-2E,C7-3E, L12-3E,P4-2NE
    b. M9:C5-1s,SP5-1s
  6. Availability: only available on DC-8, M9.
  7. Sample images: as linked below
    1. Liver cancer contrast image
    2. Cholecystic Polypus contrast image
  8. Format: as linked here.  

Philips

Siemens

Toshiba

Task Force Objectives

  • Help promote contrast ultrasound (CEUS) as a useful, low cost, radiation free imaging modality in pediatric imaging.
  • Develop relationships with manufacturers, regulators, media, other imaging organizations, and appropriate advocacy groups.
  • Explore ways of developing CEUS as a useful, practical imaging tool, including clinical trials and off label use.
  • Encourage scientific research involving CEUS
  • Help educate SPR members, pediatricans, and parents about the benefits of CEUS in pediatric imaging.
  • Help coordinate/support multicenter clinical trials involving CEUS

Task Force Members

Kassa Darge, MD, PhD, Chair, Children's Hospital of Philadelphia
Beth McCarville, MD, Vice Chair, St Jude Children's Research Hospital
Susan J Back, MD,  Children's Hospital of Philadelphia
Carol Barnewolt, MD,  Children's Hospital, Boston
Dorothy Bulas, MD, Children's National Medical Center, Washington DC
Jamie L Coleman, MD,  St. Jude Children's Research Hospital - Webpage editor
Jonathan Dillman, MD, Cincinnati Children's Hospital
Lynn Fordham, MD,  UNC School of Medicine
Harriet Paltiel, MD, Children's Hospital Boston
Frank Volberg, MD, Georgetown University

Links to Organizations

  • AIUM - American Institute of Ultrasound in Medicine
  • EFSUMB - The European Federation of Societies for Ultrasound in Medicine and Biology
  • ICUS - International Contrast US Society
  • SPR - The Society for Pediatric Radiology
  • SRU - Society of Radiologists in Ultrasound

Images/Cases

Dr Paul Sidhu, Dr Maria Sellars, and Dr Annamaria Deganello at Kings College Hospital, London

Child with Focal Nodular Hyperplasia, with early enhancement, demonstration of central scar, and prolonged enhancement, effectively excluding malignancy.

@Carmina Duran. MD. UDIAT-SDI, Corporació Sanitària i Universitària Parc Taulí, Sabadell, Spain.

Urethra Normal

Posterior urethral valve

ceVUS video clip shoing vesicoureteral reflux, with a normal urethra on transperineal voiding images

  

                                                                                                 

 

 

 

@Frederica Papadopoulou, MD; Thessoloniki, Greece

@Beth McCarville, MD

Contrast Enhanced CT shows Liver Metastasis from Transitional Cell Carcinoma in a 16 year old boy.

Non-Contrast Enhanced Sagittal Ultrasound Image using Contrast Specific Software. Background tissue appears blue.

 

Early Arterial Phae after IV administration of a perflutren contrast agent. The contrast agent appears orange. The liver metastasis shows enhancement during this phase.

Portal-venous phase shows washout of contrast from the metastasis, a feature typical of malignant liver lesions.

  

 

@Kassa Darge, MD, PhD

 

           

CEUS with the bladder full of microbubbles and refluxing into the right ureter. Clear depiction of a right vesicoureteric reflux. No reflux on the left. Contrast specific technique with color overlay and subtraction makes the reflux detection much easier

 

CEUS with microbubbles in the right renal pelvis which is not markedly dilated. Contrast specific technique with color overlay and subtraction makes the reflux detection much easier

@Kassa Darge, MD, PhD

 

 

 

Contrast-enhanced image with color overlay showing reflux into the intrarenal collecting system.

 

Contrast-enhanced image with color overlay showing reflux, with grey scale subtracted.

@Kassa Darge, MD, PhD

CeVUS - Liver Laceration & Kidney Perfusion Defect Not Seen On Grey-Scale Ultrasound

@Doris Franke, MD - Medizinische Hochschule Hannover

 No definite abnormality seen

Small hematoma in hepato-renal space

 

 

Y-Shaped liver laceration and major perfusion defect lower pole, right kidney